CEFSAR questions NAFDAC’s delay in banning toxic herbicide amid growing health concerns

Atrazine, a widely used herbicide in Nigeria and across Africa, has long been a staple in controlling annual grasses and broad-leaf weeds in crops such as maize, sorghum, and sugarcane.

Despite its agricultural benefits, this chemical has recently come under intense scrutiny due to its alarming effects on the environment and public health, particularly as an endocrine disruptor.

Atrazine’s mechanism of action as a puberty blocker and sex changer stems from its interference with key hormonal pathways, which regulate estrogen and androgen production.

The herbicide’s ability to induce aromatase, an enzyme that converts androgens (male hormones like testosterone) into estrogens (female hormones like estradiol), has profound consequences, especially in amphibians.

Aromatase Induction and Feminization: Atrazine’s upregulation of aromatase leads to an imbalance in sex hormones, particularly in amphibians.

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Studies, such as the one by Hayes et al. (2002), have shown that exposure to Atrazine results in the feminization of male amphibians like the African clawed frog (Xenopus laevis). In these frogs, increased estrogen levels caused by Atrazine have led to the development of ovaries in genetically male frogs, effectively altering their sex and leading to hermaphroditism.

Disrupting the Endocrine System: Atrazine also interferes with the hypothalamic-pituitary-gonadal (HPG) axis, a vital system regulating reproductive function and sexual development. By inhibiting the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), Atrazine delays puberty and sexual maturation in both males and females.

Research by Cooper et al. (2007) demonstrated that Atrazine suppresses the secretion of LH in rats, delaying the onset of puberty in males by disrupting the signaling pathways that regulate gonadotropin-releasing hormone (GnRH) in the brain.

Lowering Testosterone Levels and Delaying Puberty: Atrazine’s impact extends to reducing testosterone levels by affecting Leydig cells, which are responsible for testosterone production in males.

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Lower testosterone levels not only delay puberty but can also lead to the demasculinization of males. Stoker et al. (2000) found that exposure to Atrazine in rats delayed puberty and altered reproductive development by reducing testosterone production, which could lead to the development of female traits in genetically male organisms.

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Given these serious risks, Nigeria’s National Agency for Food and Drug Administration and Control (NAFDAC) has announced an outright ban on Atrazine, effective from January 1, 2025.

The directive comes after growing concerns over the herbicide’s toxic effects on humans, crops, and the environment. Atrazine’s residues have been one of the factors leading to the rejection of farm produce like vegetables from the European Union, further emphasizing the global awareness of its dangers.

CEFSAR Raises Concerns Over Delayed Implementation

However, the Centre for Food Safety and Agricultural Research (CEFSAR) has raised questions about the delayed enforcement of the ban. “Why postdate the effective date of the ban despite the verified toxicity and hazardous nature of Atrazine?” asks Professor Qrisstuberg Amua, Executive Director of CEFSAR.

The organization is concerned that allowing the continued use of Atrazine for another year poses unnecessary risks to public health and the environment.

CEFSAR’s stance is that NAFDAC’s delay contradicts its mandate to ensure the safe and responsible use of agrochemicals. The organization is calling for immediate action to protect consumers and the ecosystem from further exposure to this hazardous chemical.

As the agricultural sector in Nigeria and Africa continues to rely heavily on herbicides like Atrazine, it becomes increasingly critical to weigh the benefits against the potential long-term harm.

With evidence mounting on the adverse effects of Atrazine, particularly its role in disrupting endocrine systems and causing reproductive issues, the call for stricter regulations and faster implementation of bans becomes louder.

The case of Atrazine serves as a reminder of the need for vigilance in the use of agrochemicals, ensuring that the quest for higher crop yields does not come at the expense of human health and environmental safety. CEFSAR’s concerns underscore the urgency for NAFDAC and other regulatory bodies to act decisively and swiftly in banning toxic substances that pose significant risks to society.

This detailed story provides background, explains the scientific mechanisms, and addresses the concerns raised by CEFSAR regarding the delayed ban on Atrazine.

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